All posts by Carmen Gomaro

Carmen Gomaro - leading international news and investigative reporter. Worked at various media outlets in Spain, Argentina and Colombia, including Diario de Cádiz, CNN+, Telemadrid and EFE.

Mijail Khodorkovsky, Russian opponent in exile: "Putin knows that Russia would hand him over in exchange for the end of sanctions, that is why he will not leave power"

Just 20 years have passed since Mikhail Khodorkovsky (Moscow, 1963) went from being the richest oligarch in Russia to becoming the most famous prisoner in the country. He served 10 years in prison in cells overlooking the ice and today he wears the same timid look that always made it difficult to believe that he was Vladimir Putin's most hated opponent.

The Russian leader himself ended up granting him a pardon at Christmas 2013.. Since then he has lived in exile in London, where he continues to get into some puddles. He explicitly supported the armed rebellion of mercenary leader Evgeny Prigozhin even though he had no sympathy for Wagner's boss.. “When Putin arrived, it seemed to me that we were heading towards a truly democratic path, but I was wrong,” he explains to EL MUNDO during a brief visit to Spain, a country whose transition model interests him.. He believes that “since 2014, Russia has been falling, step by step, to a practically formalized regime of dictatorship.”

Is the end of the regime near due to the war? Or did the war happen because the regime has no future? During his terms, Putin undertook warlike actions on four occasions to solve his government's problems.. Now you have started a war again because you have felt that your support within Russian society is falling. You called on Russians to support Evgeny Prigozhin's mutiny. Do you not trust a democratic transition? For a regime change apart from a general atmosphere in society, there has to be a collapse, a failure within the regime. Of course, there are going to be bad guys on one side and the other.. Prigozhin was one of those bad guys, but he weakened the regime significantly. A peaceful decline of the regime is possible, provided that the regime realizes that there are other options.. I will give an example so that I can be understood.. Around 200,000 or 300,000 people took to the streets of the capital of Belarus, Minsk, in 2020.. They were protesting against the falsification of the elections of the president of Belarus and had the support of Belarusian society. However, when they approached the prison where the political prisoners were held, the doors were closed and they stopped there even though they could have broken them and freed the inmates.. There the Belarusian revolution ended and a period of reaction began that has left all opponents emigrated or in prisons.. What happened in Belarus teaches us a lesson: if you are not willing to go to the end, do not take people out into the streets. Do you then believe that Putin will die with his boots on? Everything seems to indicate that this will be what will happen. If Putin had left power definitively in 2008, he would have remained in people's memories as a not-so-bad president.. When he returned to office in 2012, people took it worse. In the Spanish transition, which I know a little about, there were a series of guarantees [for the previous regime]. After 2022, I don't think anyone can guarantee anything to Putin. Because Putin's surrender is worth lifting sanctions and a future Russian government will be willing to hand Putin over [to international justice] under those conditions.. He knows it perfectly. That is why he will maintain power as long as he can. If Putin takes kyiv, if he takes over most of Ukraine and looks victorious…. What will he do next? That's what I try to explain to European politicians.. Imagine: you are president of Russia, you have occupied Ukraine, a place where two thirds of the population hate you and they have set up a guerrilla, partisans.. You have a destroyed territory, and you have to spend money on reconstruction, because otherwise there will be waves of refugees to Russia. It also has a million people who are already used to being paid for killing, because they have gone into combat to earn 10 times more than before and, of course, they want to continue with the 'banquet'.. At that time, it has been 10 years in which the country's economy is not growing, so the well-being of the people rather falls.. And on top of that, no one can take away the sanctions.. What are you going to do? Go for more. In my opinion it is obvious. And what exactly would it mean to go for more? People forget about the ultimatum that Putin gave at the end of 2021: retract NATO to the borders of the year 1997. That means: Baltic countries, Poland…. You may even decide to include East Germany. Putin's thinking is that Europe will ultimately hand over Ukraine. And then he's going to hand over the Baltics, and with that NATO breaks up, so he can do whatever he wants afterwards.. Putin [with Kiev already subdued] would try to recruit people in Ukraine for his army: the country would be collapsed, with nothing to do, there would be people willing to fight against Putin and also for Putin: that is the Donbas model. I estimate he could recruit a million people, enough to take the Baltics. How did Putin go from the almost bloodless annexation of Crimea and the covert, limited interference in Donbas of 2014 to the full-scale invasion of 2022? Without a doubt those Such erroneous decisions were made because their environment was reduced as a result of COVID. We know the names and surnames of the people who led to those erroneous decisions.. [Businessman] Yuri Kovalchuk, [pro-Russian oligarch] Victor Medvedchuk and [FSB intelligence service general Sergei] Beseda. We know Kovalchuk's ideology: imperialist and traditionalist. Medvedchuk did it more for money: he has invested more than 1 billion corrupting Ukraine, and it worked for him. And the other [Beseda] told Putin that the regions of Ukraine were going to welcome him with flowers. It seems that the regime defrauded itself. This is how authoritarian regimes usually end: they lose their link with reality. Between 2013 and 2014 there was only one big difference between both countries: Ukraine was more or less democratic and Russia was more or less authoritarian.. If Putin had been in a different state of mind he could have bought or leased Crimea.. We could have been like France and Belgium. The situation turned out to be completely different. Ukraine began to consolidate itself even more as a nation, in ten years Ukraine has made great progress and Putin finds himself with a state that is considered totally different from Russia. 2014 was Putin's mistake, and 2022 is its continuation. What attitude should Europe have towards Russia? There are two bad ideas. The first is to talk about Russia going to disintegrate, which is not realistic and if it were it would be dangerous.. And in any case it serves to scare people and rally them around Putin. The second bad idea is sanctions: Europe is a rule of law, so every limitation of rights must be described by law. Unfortunately, there have been almost two years of sanctions, and there are still no strict rules on how to get out of the sanctions.. It should be clear to anyone. What do you think would happen if Putin dies tomorrow? If a brick falls on Putin's head tomorrow, [Prime Minister] Mikhail Mishustin would be the successor.. Russian history suggests that it would not retain power for long: there were transition periods after Stalin and after Brezhnev. One of the main missions of the opposition, apart from stopping the war, is to influence that process. To overthrow a dictatorship, apart from a general atmosphere of society, there has to be a collapse within the regime itself: the Army is not willing to shoot against the people.

The Flemish actress who makes Belgian politicians tremble with her Gila-style parody videos

Who. She is a Flemish actress, screenwriter, writer and comedian who has become very popular since the return of summer for a television series and her videos on Instagram parodying local politicians.

That. In just 90 seconds, Baeten, with Katrien's 'alter ego', makes fun of the scandals of the week, exposing its protagonists, with a lot of irony, self-confidence and closeness, sometimes more effective weapons than fierce criticism.

What can you do if you are trapped in a loop, in a mediocre and bland job, with no future and in which you do not get the recognition you deserve, but which you cannot give up no matter how hard you try? In addition to the personal story of one in three readers of this paragraph, that plot is the starting point of De Laatste Dag, The Last Day, a recent humor miniseries starring Elisabeth Lucie Baeten, an actress, writer, screenwriter and comedian. which has become the sensation of the moment in the flamenco world.

Every morning, upon waking up and leaving the house on the way to a fictional television, the character of Lucie (played but also created by her) repeats out loud: “Today is my last day.”. She wants to be promoted but her boss ignores her, her colleagues have their own misfortunes and the circumstances are not on their side.. She wants to resign, she knows she should resign, she is determined to resign, but she never succeeds, because something always happens.. A meeting that cannot be postponed, a pregnancy test with a false positive, a crush with the new guy in the office.

The plot doesn't have much mystery: misunderstandings, flirtations, easy jokes, unexpected twists that are completely expected.. But it has had some success in Flanders, managing to connect with the millions of people who are bored in their chair for eight hours five days a week and feel identified with that very Belgian mixture of pacelessness, routine, lightness, overreaction and improvisation. But above all, it has raised the profile of its protagonist and person in charge, whom some compare – with somewhat questionable criteria – with the North American Lena Dunham, the creator of the also successful Girls.

Elisabeth defines herself as an “irritating optimist” and is the author of books such as: Living in the Now. Guide to what to do, what not to do and what the hell is happening in these confusing times, quite a statement. He started out doing everything, but he found an immediate niche on Instagram with the express mockery of the week's protagonists.. No one wants to be a victim of their sharp and ironic darts, but at the same time no one wants to be completely left out, because they have become a way of determining who matters and who doesn't in current Belgian times.. “Even the prime minister follows me,” he boasted these days.

His recent videos do not last more than a minute and a half and the internet has loved them. In Gila style, she presents herself as Katrien van Politiek PR, Katrien from political public relations, and has telephone conversations with the enemy, which are the local leaders who get into trouble, get out of control drunk or make fools of themselves with delusional excuses. They are not biting, but they are accurate and close, and that is precisely why they work so well. They make people laugh without needing to destroy, but they are devastating from forced innocence.

Is he a celebrity? Well, he is earning it, but in reality, if he were, or something similar, it would only be in half of the country. The other half, the Walloon and French-speaking, have no idea who he is.. There are no references in their media, there is no follow-up on the street. The division in the country, for these things, is total or almost, and there are few stars capable of covering the entire national universe.. It is a double-edged blade: on the one hand they live better, without many stresses and too much cultural friction, but on the other hand, ignorance becomes dull and is very difficult to smooth out.

The pro-European opposition obtains the majority in the legislative elections in Poland, according to partial results

The mere prospect of a change of Government in Poland after two consecutive terms under the Law and Justice party (PiS) has caused sharp increases in the financial markets and the prospect of a reconciliation with Brussels that will translate into the unlocking of community funds once once restored to the rule of law, sowing optimism in a large part of Polish society. The rise to power of a pro-European and liberal tripartite led by former Prime Minister and former President of the European Council, Donald Tusk, is inevitable, but there are dark clouds on the horizon.

President Andrzej Duda, who traveled to the Vatican coinciding with the possible burial of the party that elevated him, will announce the results of the elections this Monday. With almost 80% of the vote, the PiS, as the exit polls indicated, will prevail at the polls, but will not reach a parliamentary majority. PiS's chances of staying in power are practically zero, but Duda will give itself the deadline established by law, 30 days, to say which candidate it will appoint to form a government.. And PiS, as the party with the most votes, has already claimed that right.

“In accordance with the rules of democracy, it is up to us to try to build a parliamentary majority, and that is what we will do,” declared the outgoing prime minister, Mateusz Morawiecki, the big loser of these elections.. If PiS fails to remain in government, and everything indicates that it will not be able to do so, Morawiecki will pay a double price: he will no longer be seen as the “heir” to Jaroslaw Kaczynski's party and as a successful candidate to succeed Duda.

“Morawiecki has done everything wrong. It was supposed to become PiS's ticket to the metropolitan middle class and improve relations with the EU. But he became the tribune of the people, appealing to the less well-off. A completely wrong strategy, the effects of which we are seeing,” says political scientist Rafa Chwedoruk.

According to the PIS chief of staff, Brudziski, the party would begin to talk about a coalition with the farmers' party (PSL), although he did not explain why, since they still have not joined forces, so the only card they will be able to play It is that of transfuguism.

Because in the PIS there is a feeling that the electoral results are good. “It is a true success after eight years, after Covid, after the war in Ukraine, after inflation, after the attacks we have suffered, that we have come this far. And all this is essential to form a government, because we will probably be the first to present our candidate,” says deputy Bartosz Kownacki.

Analysts believe that PiS's strategy will be to buy time. Its first only interlocutor will be Konfederacja, a nationalist-libertarian formation now led by 36-year-old businessman Slawomir Mentzen.. His programmatic ideology converges with that of PiS, although the latter is even more radical, since Mentzen wants “no Jews, no homosexuals, no abortion, no taxes, no European Union.”. The problem is that this formation has not achieved enough support to form a majority. “We have played too lightly. We removed the harshest demands from the program, including the death penalty in our program. “Such are the consequences of looking like other groups,” the party analyzes.

There is agreement that PiS has made serious mistakes, which the liberal political spectrum appreciates. One of them is that they have not adjusted their program to the demographics. “To put it brutally, in the fact that some of their 2019 voters are no longer here and instead of seeing the new reality, they have closed their eyes. This Government has become intoxicated with power to the point of unconsciousness. The symptoms are confusingly similar to those of alcohol poisoning, so the ability to solve problems decreases, while the belief that one can cope with them increases,” explains Professor Jaroslaw Flis.

Polish observers maintain that the PIS strategy will be to boycott a possible government coalition between the Civic Coalition, the center-right Third Way party, and the New Left with 30. This tripartite would add 248 seats. “This coalition will not bring stability, so the legislature will either be short or it will not begin to work,” says Kownacki, who does not even rule out holding new elections.

The three formations, although with nuances, are pro-European and share an economic model. The priority they have set is to do the impossible for Brussels to unlock the funds from the National Reconstruction Plan. This is a massive financial injection of 158.5 billion zlotys. “I make a solemn promise that the day after the elections I will go and unlock the money from the National Recovery Plan, and we will all notice,” said Tusk upon seeing himself as the winner of the elections.

“Let's bring this money back. We will bring more than 100 billion zlotys to Poland. PiS didn't want that money, but we're going to be able to say goodbye to it, and we need it. That is why today we say: the Third Way or the third legislature of Law and Justice”, is the message from the leaders of that formation.

But according to economists, the most urgent tasks facing the new Government and Parliament include the approval of the budget for 2024, as well as important decisions on anti-inflationary shields for the forecasts of macroeconomic indicators (VAT on food, a possible extension of the solutions that lower the prices of energy vectors). Final decisions on the possible extension of credit moratoriums (and the definition of the announced income threshold) will also have to be made before the end of the year.. This is all the more important since Poland will have one of the highest deficits in the European Union – in real terms, around 5.2% – according to Banco Santander Poland. Only Bulgaria, Slovakia, Malta and Belgium will have it worse.

In a statement to the media, President Duda limited himself to celebrating the high turnout in the elections, almost 73%, and the democratic maturity of the Polish people.. “Elections are a kind of test of the extent to which we are a democratic, mature and supportive society when it comes to deciding for ourselves. Many thanks to all the compatriots who went to cast their vote,” he declared in Rome.

Duda also thanked everyone who participated in the referendum, which has been invalidated due to lack of quorum.. It only registered a participation of 7%. Former Defense Minister and PiS vice-president Antoni Macierewicz blamed the failure on the fact that, according to him, voters were coerced into not taking the referendum ballots.. “It was a criminal action,” he said.

Daniel Noboa, the electoral magician who has conquered Ecuador

Almost no one paid attention to him when the presidential campaign began in July. Daniel Noboa was semi-unknown inside and outside Ecuador, but he had an initial advantage, his last name. Because there is not a single Ecuadorian who does not know his father, the banana magnate Álvaro Noboa, a five-time presidential candidate and one of the richest men in the country.. From the Pacific to the Amazon, passing through the volcanoes of the Andes.

At only 35 years old, Noboa landed in the early elections almost in the dark, forgotten by the media and the public, at the head of National Democratic Action (ADN), an alliance created by himself with an obvious nod to his father with that DNA of his initials.. Two years earlier he entered the National Assembly with the support of the Socialist Party, the same party that on other occasions accompanied his father in his failed presidential attempts.

Many memes have spread since then on the networks demanding paternity tests due to the great differences between the torrential Álvaro, famous for his phrase “Ser created a mess!” and the restrained Daniel, who has made the most of his academic training to consolidate his campaign towards the Carondelet Palace.

His mother, the doctor Annabella Azín, whose brigades of the New Humanity Crusade Foundation have treated thousands of patients from the most disadvantaged sectors, says that Daniel seems like a young old man, always so responsible, since he was 16 years old as a yard supervisor. From containers. But the reality is that he enjoyed the good life and music, capable of imitating any singer.. Until his father gave him an ultimatum: to study.

Political master's degrees at George Washington University and Harvard, business administration at Stern in New York, and management at the Kellogg School have finally enabled him to become an outsider in the campaign with which Correism wanted to regain power.. And really without Noboa, Rafael Correa would already be packing his bags to return to his country through the front door.

Everything changed when in August Colombian hitmen ended the life of anti-corruption journalist Fernando Villavicencio in Quito, an assassination that hit the country so hard that its citizens turned on their televisions en masse days later to witness the only debate between candidates in the first round.. And Noboa arrived at the television studio with the bulletproof vest that made him famous.. According to what he himself confessed to EL MUNDO, it was a decision he made hours before because “we had to remind people that there is a candidate here who is not here because he was murdered.”. “It was a clear message of protest and the emergency situation in which we live.”

Noboa, an attractive young man, then attracted all eyes in the debate. His intellectual solvency did the rest. In the blink of an eye it went from 2% support to more than 20% in the face of a country that was licking its wounds and looking for urgent solutions. His electoral strategy from day one, employment for young people plus the fight against drug trafficking, did the rest.

A transcendental part of the comeback in both rounds has been played by his wife, the fitness influencer Lavinia Valbonesi, who knew how to multiply the successes of her husband's campaign on social networks, especially on TikTok. 50% of voters in Ecuador are very young, habitual consumers of short videos on the Chinese network. They all wanted something new, an outsider far from the old politics riddled with corruption.

The muscle of the Citizen Revolution in the second round closed the gap, it seemed that the process was taking a long time for Noboa. And when the Correísta González rebounded the most, came the second blow of the centrist leader, who defines himself as a “moderate social democrat.”. Half a million life-size cardboard Noboas took to the streets because the candidate had run out of money for the campaign, but they had a cardboard factory that quickly carried out the order.

Lavinia, his wife, took on the challenge: “I already found out that my husband is being robbed all over the country”. And then, as Álvaro Noboa would surely say, the chaos broke out again.. The cartoon of Noboa sitting at a family's table, in the bed of some young girls, in the hairdresser's, in the church…. Popular ingenuity took him to a massage house to receive therapeutic treatment. In a single stroke, the electoral magician had added social media users as a fundamental part of his surprising path to the presidency.

They sue the public company Salvamento Marítimo for not respecting workers' rest hours

A senior special operations technician, backed by the CSIF union – the majority among public employees – has sued the public company Salvamento Marítimo for not respecting staff rest hours and failing to compensate for overtime, which he considers It represents a substantial modification of working conditions that is not justified and without notifying the workers or their representatives.

According to the lawsuit filed before the Social Court of Santa Cruz de Tenerife and the complaint registered with the Labor Inspection, to which EL MUNDO has had access, everything changed this summer, when the company decided without prior notice to change the rules of game of these workers, who are dedicated to planning, coordinating and monitoring rescue, prevention and anti-pollution operations.

Until then and since 2007, all the technicians that Salvamento asked to be mobilized for an emergency (never related to the rescue of people, but to stranded ships, floods, fires, fuel extraction and fight against pollution) requested through the employee portal authorization to travel. If the transportation and accommodation did not take place in a maritime unit of the public company, then the technician contacted the El Corte Inglés travel agency to make the reservations.. Every day, the technician prepares a report with the activity carried out and the hours allocated to it and, upon his return, he makes a settlement of the expenses he had had to assume (tolls, food allowances, etc.) and requests authorization for it to be carried out. They compensated him for the extra hours worked, so that for each extra hour worked during the trip, they gave him 2 hours of rest -unless they were at night or on Saturdays, Sundays and holidays, in which case the compensation would be 2 and a half hours- , as stated in the Collective Agreement to which the worker is assigned.

Furthermore, according to the agreement, working time begins counting from the moment the worker leaves the base or home and until he or she returns, and working time is understood not only as the ordinary day and travel time, but also “one third of the rest periods due to being away from home”, which would then be returned to him during free hours along with the corresponding amount for the extra hours.

This summer, the complainant technician, who works at the strategic base to combat pollution in Santa Cruz de Tenerife, received an email on June 16 asking him to support the Navy during the acceptance tests of the Isaac submarine. Peral, for which he would have to travel to Cartagena from the 20th to the 22nd of that month. Upon his return, on the 26th, he presented a settlement of expenses and a report of hours worked, but the latter was rejected.. The employee was given the option to “repeat the timesheet deleting the rest third and submit it again.”

“Since 2008, senior special operations technicians in Maritime Rescue logistics bases have been enjoying compensation in free time for two concepts: overtime and rest time.. For this reason, it is evident that the company unilaterally, without carrying out any procedure and without justifying cause, has proceeded permanently and not temporarily to substantially modify the rights recognized in the applicable Collective Agreement, both in which refers to the compensation of overtime generated during mobilizations, as well as the consideration of effective working time for travel and one third of the rest periods for being away from home, as well as the payment of subsistence allowances. and travel expenses for such mobilizations,” the lawsuit states.

7,500 hours to compensate

Due to this change in criteria, CSIF estimates that in total there are about a thousand work days, the equivalent of 7,500 hours, that have not been compensated to the workers.

Given the possibility that the company has changed its criteria and now considers that these technicians cannot continue benefiting from these compensations included in the agreement, the complainant recalls that the jurisprudential criterion of the “most beneficial condition” must prevail, which implies that a company cannot unilaterally eliminate advantages that it offered to workers on an ongoing basis and that have been consolidated as part of the contractual relationship. “We would find ourselves facing a more beneficial condition, maintained voluntarily, unilaterally, peacefully and permanently by the company, so the only way to proceed with its suppression would have been through the procedure regulated in article 41 of the Labor Statute,” relating to breaches of the agreement.

Both the complainant and CSIF defend that the company has substantially modified the working conditions without giving 15 days' notice to the employees or their representatives, and without justifying it for economic, technical, organizational or productive reasons, for which they ask the Court to declare annul your decision and compensate the worker.

In Spain there are only eight technicians of this type: two in Tenerife, one in Cartagena (who works with an area manager), one in Castellón (together with an area manager), one in Seville, two in La Coruña and one last in Santander. All are governed by the Collective Agreement for ground personnel of the Maritime Rescue and Safety Society, which stipulates that the working day must last 37.5 hours per week – with a maximum annual count of 1,711 hours.

In addition to the legal claim, CSIF has filed a complaint with the Labor Inspection, “given the impossibility of family conciliation and the right to rest that occurs when having to be permanently available for possible emergencies 24 hours a day, 7 days a week and not establishing on-call shifts, which results in an increase in work pressure and a decrease in performance due to lack of regular rest,” they lament.

The union considers that to guarantee rest without entailing an additional cost for the company, the ideal would be to establish a shift system, “ensuring the presence of a technician available 24 hours a day, on alternate weeks, at each logistics base,” but according to The public company union has rejected this proposal “understanding that there are not a sufficient number of emergencies.”

The union recalls that in past years some technicians have attended up to six emergencies, “spending more than 150 days away from home,” without the company wanting to compensate them for the overtime worked.

Fentanyl: the drug that everyone fears, but it is routinely used in hospitals

In recent weeks, a drug, until now unknown to most of society but very popular in hospitals, has begun to make headlines.. All because of the epidemic of overdoses and deaths that is causing throughout the United States.

So much so, that American authorities have begun to install what they have called an “opioid rescue kit” next to defibrillators and fire extinguishers in order to save the life of someone who has suffered an overdose.

Fentanyl, is it a new drug?

Not at all. Fentanyl was first developed in 1960 and has been used in Spanish hospitals for decades to treat acute pain in certain cases..

It is also dispensed in pharmacies, always under strict controls, so that certain patients who suffer severe pain that does not allow them to lead a normal life can improve their daily lives.

Is it very powerful?

Fentanyl is an opioid that is synthesized in the laboratory and is, according to various studies, about one hundred times more powerful than morphine..

This makes it an ideal drug to control the intense pain suffered by some patients in areas such as the operating room, oncology or intensive care.. In fact, in 2017 fentanyl became the most used synthetic opioid in medicine.

What effects does it have on the human body?

The desired effects include relaxation, pain relief and a feeling of well-being, but depending on the dose they can also produce sedation, drowsiness, confusion or even nausea and vomiting.. More or less the same effects that other opioid pain relievers produce.

If they administer it to me in the hospital, do I have to worry?

Whether you are admitted to the hospital or suffer an accident and the ambulance medical team administers a dose of fentanyl, you don't have to worry about a thing.. Medical fentanyl is safe and is not given to patients lightly.. You are not going to become an addict by receiving a few doses punctually after a major surgery or after having broken several bones.

In the case of cancer patients or patients who suffer significant pain, when their doctor decides that they should take it continuously or put on a patch with this drug, it is because they really need it, because no other analgesic works and only by using this one will they be able to control the pain.

What happens with a fentanyl overdose?

When the dose administered is higher than expected, or in the case of illegally manufactured fentanyl when the concentration of the drug is greater than what it is supposed to contain, the person who has consumed it will go into a coma and suffer respiratory arrest.. That is, the sedation is so deep that you will stop breathing and, if nothing is done, you will die in a matter of minutes when your heart stops beating due to lack of oxygen.

What is happening in the United States?

The problem on the other side of the ocean is so serious that fentanyl has already become the leading cause of unnatural death among Americans ages 18 to 45..

There, illegally manufactured fentanyl, not so much pharmaceutical fentanyl prescribed by doctors, has been distributed in the drug markets for a couple of years in liquid, pill or powder form..

Its potency has made it very popular, and it is not uncommon for those who manufacture it in clandestine laboratories to mix it with other substances such as heroin or cocaine to enhance its effects.

Naloxone, the antidote for overdoses

In the opioid rescue kits that can now be seen throughout the United States, we find a nasal spray that contains another medication: naloxone.

This drug has the ability to neutralize the effects of opioids, including fentanyl, in a matter of seconds. That is why it has become the new American lifeline against the epidemic that the country is experiencing, and in fact the CDC recommends to its citizens that if they see a person who seems to be suffering from an overdose, do not hesitate and administer this intranasal antidote. .

What is the situation in Spain?

According to the National Police, “illegal fentanyl trafficking has not reached Spain yet”. But if we look at the latest data from the Survey on alcohol and other drugs in Spain from the Ministry of Health, the sporadic use of fentanyl is 14% in 2022 when in 2018 it was 1.9%.

The sale of fentanyl for medical use in pharmacies is closely monitored, since it is carried out under strict controls, and within hospitals, the blisters, pills and patches that contain this medication are also subject to strict controls that include justifying each dose that is given. manages

The problem would be that, just as is happening in the United States, this fentanyl manufactured illegally in an almost artisanal way is landed in the drug markets of our country.. Something that only time will tell us if it will happen or not.

Access to orphan drugs in Spain: 49 unfunded drugs and 26 months of waiting

The figures seem to have improved in recent months, but they are still far from being the desired ones. Access to orphan drugs in Spain continues to be an issue that, despite being considered a priority, is advancing slowly.

It is enough to analyze the data from the latest quarterly report of the Spanish Association of Orphan and Ultra-orphan Drug Laboratories (Aelmhu), which shows the lights and shadows regarding the availability of these drugs in our country.

With data updated as of August 31, the document reveals that although 85% of orphan drugs authorized in the European Union arrive in Spain and have a national code (CN), only 52% of them are financed. Along with this, it is reflected that 49% of the drugs have been financed with restrictions. That is to say: with limited indications or with unfunded indications.

To know more
Health. Orphan drugs in Spain, leaders in clinical research but unequal in access to treatment

Orphan drugs in Spain, leaders in clinical research but unequal in access to treatment

Neurology. Approval for public financing of the first oral drug against spinal muscular atrophy

Approval for public financing of the first oral drug against spinal muscular atrophy

From these data it is also clear that there are 22 medicines that have marketing authorization in the EU, but not with a national code in Spain: 15% of the total.

The figures referring to these last four months are an example of how the trend is improving, but not at the pace that would be desired: between the months of May and August, 2 new national codes were assigned and the financing of 9 new orphan drugs was approved, until reaching 126 orphan products with national code and 77 financed products.

Orphan drugs in the EU and Spain

– There are about 202 products with orphan designation and trade name. Of which, 148 orphan drugs have a marketing authorization (MA).

– Likewise, of this figure in Spain, 126 have a national code and 77 are financed by the National Health System (SNS).

– From 2020 to this year, the time elapsed between the designation of the national code and incorporation into the SNS has been reduced from 33 to 26 months.

Average waiting time

Regarding the average waiting times between obtaining the national code for a drug and its incorporation into the SNS, the report points out that the figure “remains unchanged”, being the same as that of April 30: 26 months. If this figure is compared to last year, which was 34 months, the situation seems to have improved; but not if compared to 2021, in which the average waiting time was 24 months.

Along with this deadline, Aelmhu highlights that there are 49 orphan drugs with a national code not financed by the health system: 28 not financed by resolution and 21 under study or without a request for financing.

Furthermore, a notable fact is that of those 49 drugs still without financing, 21 of them had the NC before 2020. This is a clear example of why there is an urgent need to improve in this area.

Regarding this, and making a classification by therapeutic areas, the majority of unfunded orphan drugs fall within the oncological category (35%), followed by metabolic (27%), nervous system (8%), hematological (6%), anti-infectives (6%) and hormonal preparations (6%). The remaining percentage is divided between dermatological, musculoskeletal, immunomodulatory, sense organs and others.

Unfunded orphan drugs by therapeutic area Dropdown
  • 35% oncological
  • 27% metabolic
  • 8% nervous system
  • 6% sense organs
  • 6% hematological
  • 6% anti-infectives
  • 4% immunomodulators
  • 2% musculoskeletal
  • 2% dermatologists
  • 2% hormonal preparations
  • 2% others

In reference to advanced therapies with orphan designation, Aelmhu's quarterly report reflects that, as of August 31, 2023, there are 15 treatments with marketing authorization, 14 with a national code and 5 financed by the SNS.

Regarding the sources used to prepare this report, the institution indicates that they are the European Medicines Agency (EMA), the Community Registry of Orphan Medicines, the Spanish Agency for Medicines and Health Products (Aemps) and the Ministry of Health. .

From the association

Taking stock of the numbers provided by this document, Aelmhu points out to this newspaper that although “an improvement is perceived in several of the indicators” such as, for example, the number of new drugs financed by the SNS, there are others, such as waiting time until financing, which remains “very high”.

“Knowing the evolution of the indicators, at Aelhmu we are committed to making the reduction of access times a priority; advocating to request, as we have been doing for years, a change of model for the evaluation and financing of orphan and ultra-orphan drugs. In other words: an agile, predictable and transparent financing and evaluation mechanism that, in a manner agreed upon by all the agents involved, takes into account the characteristics of this type of medicines; allows a reduction in waiting times with the common objective that patients have early access to treatments, and consolidates itself as a good tool to reduce uncertainty and restore Spain's attractiveness for the arrival of innovation already approved in the European Union,” the association explains to CF.

For this reason, they advocate that, beyond the numbers, we continue to “work together” to improve the availability of treatments for patients with a rare disease, reduce waiting times and ensure that research and innovation arrive as soon as possible. , eliminating bureaucratic access barriers.

“In short, within the change of model that we request, we must always keep in mind that for patients with a rare or ultra-rare disease, in most cases, the equitable availability of an innovative drug is the only therapeutic alternative to stop his illness”, they conclude from Aelmhu.

NASA sets off for Psyche-16: the mysterious trillion-dollar 'floating mine' in the asteroid belt

The Psyche space probe is already a little closer to the asteroid that bears its name, and will reach it in the summer of 2029. After two postponements in eight days due to bad weather conditions, finally at 4:19 p.m., Spanish time, and with overcast skies, the spacecraft took off from Launch Complex 39A at the Kennedy Space Center in Cape Canaveral, aboard a Falcon rocket. Heavy from Elon Musk's Space

The odyssey to reach one of the most enigmatic objects in the solar system will travel more than 3,540 million kilometers. It will first reach Mars, where it is expected to arrive in 2026, and there it will obtain the gravity boost necessary to reach its destination in the summer of three years later.. A trip like going to the moon and back 10,000 times.

Psyche-16 is one of the largest objects in the asteroid belt located between Jupiter and Mars.. It is believed that it could have been just another planet in the solar system if it had not been for a catastrophic collision that occurred billions of years ago, which took away the mantle, leaving the core exposed to outer space, which would serve to find out exactly how It is ours.

To know more
Space exploration. The enigmas of asteroid 16 Psyche, the failed planet that contains 12 trillion kilos of metals

The enigmas of asteroid 16 Psyche, the failed planet that contains 12 trillion kilos of metals

Space. This is the ship in which four NASA astronauts will orbit the Moon: “The goal is still to land on the moon in December 2025”

This is the ship in which four NASA astronauts will orbit the Moon: “The goal is still to land on the moon in December 2025”

The result is a floating potato of 165,800 square kilometers, which if cut in half would be about 280 kilometers wide by 232 kilometers long.. It takes just four hours to orbit itself, and five Earth years to orbit the sun.. It emerged from earthly anonymity in 1852, when it caught the attention of the Italian astronomer and mathematician Annibale de Gasperis, who named it in honor of the Greek goddess of the soul.

Once it reaches the asteroid, the probe will study it for 26 months, orbiting closer and closer, until it finally crashes into its metallic soil in 2031.. It will be the first time that humanity, specifically Arizona State University (United States) and NASA's Jet Propulsion Laboratory, explores an asteroid rich in metals.

Animation of the probe approaching the asteroid. AP

“It's the first time we're going to an intermediate world. All the previous times we have gone to planets and objects that are rock and ice,” but never to a satellite like Psyche, which “could yield unthinkable findings,” said Bob Cabana, associate administrator of this space agency.

Although most of Psyche is thought to be iron and nickel, it may also contain gold and silver.. Psyche's own principal investigator, Lindy Elkins-Tanton, estimated a few years ago the value that all these minerals could have on Earth at 10 trillion dollars, but the truth will not be known for another six years.

A magnetic field like that of the Earth

“We hope that by studying the asteroid we will learn more about the iron core of other planets in our solar system, including the most important planet to us, the one we live on,” Earth, said Nikki Fox, NASA Associate Administrator for Science. .

The Psyche platform, which is 24.8 meters long and has solar panels. It is equipped with a magnetometer designed to detect and measure the magnetic field that the asteroid is believed to have, similar to that which allows life on Earth, and obtain data that would help scientists better understand the formation of the Solar System.

It is also equipped with a multispectral imager, and a gamma ray and neutron spectrometer, all designed to measure, map, survey, and solve the mystery of the geological composition and chemical elements of the asteroid.

The launch of Psyche was scheduled for 2022 but was postponed due to problems in the navigation software. The weather conditions and having more time to verify the ship's cold gas and nitrogen thrusters once again postponed the ship's takeoff on two occasions since last day 5.

They find a record of energy in the emission of a pulsar, challenging theories about stars

The astronomer Rafael Bachiller reveals to us in this series the most spectacular phenomena of the Cosmos. Topics of pulsating research, astronomical adventures and scientific news about the Universe analyzed in depth.

Gamma radiation around 20 teraelectronvolts has been detected in the Vela pulsar. This discovery challenges existing theories about neutron stars.

Star Corpses

When they run out of nuclear fuel, stars with masses greater than 10 times that of the Sun explode as supernovae.. The inner region, whose weight is no longer supported by the energy of nuclear fusion reactions, collapses to leave behind a hyperdense star (only about 20 kilometers in diameter) known as a neutron star.. A spoonful of this stellar material has as much mass as Mount Everest.

These stellar corpses rotate very quickly, generating periodic pulses of radiation, which is why they are also known as pulsars.

Pulsars are, therefore, rotating stars that behave like gigantic magnets. The electrons subjected to their very intense magnetic fields are trapped in the polar regions, forming, during this process, pulses: very narrow jets of radiation that behave like the beam of light from a lighthouse.. Every time this type of lighthouse directs its light beam towards our telescope we receive a short burst of radiation.

Artist's image of a NASA pulsar Eleven spins per second

One of the best studied pulsars is the one located 936 light years away in the southern constellation of Vela.. This stellar corpse, which was formed in a supernova explosion that took place 11,400 years ago, rotates with devilish speed: it makes 11 revolutions every second, and is the object in the sky with the highest persistent emission of gamma rays.

An international team of researchers coordinated by Arache Djannati-Ataï (from the French CNRS) have now used the High Energy Strobe System (HESS) telescopes, installed in Namibia, to study the gamma-ray spectrum of the Vela pulsar. And what they have found is record-breaking radiation.

The HESS telescope array in Namibia HESS

Indeed, scientists have observed emissions in the range of 20 teraelectronvolts (TeV). Let us remember that an electron volt (eV) is the energy acquired by an individual electron subjected to an electric potential difference of only one Volt.. Typically, visible light photons that reach us from the Sun are between two and three eV, approximately. Therefore, each of the photons now detected in the Vela pulsar is about 10 billion times more energetic than one of those visible light solar photons.

Furthermore, the gamma-ray spectrum of this pulsar shows that the photons do not form a decreasing continuum with energy, but rather a disruption is observed with a maximum in the TeV range.

Until now, it was known that pulsars emitted up to ranges of several gigaelectronvolts (GeV, one billion eV), and the well-known pulsar of the Crab Nebula (6000 light years away, in Taurus) was the only one that reached TeV, with a spectrum continually decreasing in energies. The behavior of the Vela pulsar is starkly different.

Extreme acceleration

There is broad consensus that gamma radiation from pulsars is created by the acceleration of electrons from the surface of the star to the edge of the magnetosphere.. From here the radiation beams that are emitted into space must arise.. But the very high energies observed in the Vela pulsar require a different acceleration mechanism that takes place beyond the magnetosphere itself.

In the recreation that heads this article, the Vela pulsar appears in the center, and the edge of its magnetosphere is marked by a bright circle. Blue lines pointing outward represent accelerated particle trajectories. These could produce gamma radiation along the arms of a rotating spiral by colliding with infrared photons emitted in the magnetosphere (in red).

Although it is only one observed case, these data offer a unique opportunity to study the extreme acceleration processes of charged particles in highly magnetized environments.. They are very peculiar conditions that cannot be studied in terrestrial laboratories and that, therefore, can reveal little-known behaviors of radiation and matter.

Of course we will have to look for more cases and we all wait impatiently for the construction of the CTA (Cherenkov Telescope Array) telescope sets in the Canary Islands and in Atacama (Chile) to be able to carry out observations of much greater sensitivity than that now provided by HESS.

The work of Arache Djannati-Ataï and collaborators has been published in a recent issue of the journal Nature Astronomy. The full article can be consulted for free at this link.

Rafael Bachiller is director of the National Astronomical Observatory (National Geographic Institute) and academic of the Royal Academy of Doctors of Spain.