Although it may seem strange to you to vote on a Wednesday, for the Dutch it is nothing out of the ordinary. And they will do it again this November 22, in the middle of the week, to elect their new Parliament and prime minister after the ad
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Shifa Hospital, epicenter of the war between Israel and Hamas
The Shifa Hospital area in Gaza has become the center of combat and the focus of accusations between Israel and the fundamentalist group Hamas in a war that this Saturday marked five intense weeks of projectiles and bombs.. While the UN warns about a dramatic health situation in the Palestinian enclave and demands a ceasefire to save patients, wounded and displaced, thousands of inhabitants of the northern Gaza Strip continue making their way south in the “humanitarian pause” of Israel that could become a “humanitarian truce” if there is an agreement on the issue of those kidnapped by Hamas on October 7.
Without his return there will be no truce, Prime Minister Benjamin Netanyahu has warned again. In a long press conference on Saturday night, he added that his forces killed “thousands of terrorists,” highlighting that Hamas has already lost control of the northern Gaza Strip, accusing it of shooting at humanitarian corridors for Gazans.. “If we want peace, security and guarantee the future of Israel, we must destroy Hamas,” he declared, warning the Lebanese militia Hizbula that if it decides to intervene in the war with Hamas “it will make the mistake of its life and will change the destiny of Lebanon.” .
After denouncing “the attack and siege” by Israel against several hospitals, the Ministry of Health controlled by the Islamist group warned this Saturday of the risk to the lives of 37 newborn babies in the neonatal unit of the Shifa Hospital after being “out of service.” “while an Israeli NGO noted that two died due to the lack of electricity. The Israeli Army announced that at the request of the Hospital it will help transfer the babies to a safer hospital. “The intensive care unit, the pediatric department and the oxygen devices stopped working,” said Health Ministry spokesman Dr.. Ashraf al-Qidra while the general director, Munir Al Bursh denounced that “Shifa is under siege from all directions. The occupation surrounds it and prevents the evacuation of the wounded.”
The director of Shifa Hospital, Mohamed Abu Selmia, said that Israel demanded that they evacuate the hospital, but that there was nowhere for such a large number of patients to go.. According to him, his center “has been left without water, fuel, food, electricity and telecommunications, with thousands of people inside, including wounded, patients and displaced people.”
The Israeli military denies the accusations. In Arabic, Colonel Moshe Tetro denies that his forces have fired on Shifa Hospital and confirms in its surroundings “armed clashes between soldiers and terrorists” while informing Gazans that “the east side of the hospital” remains open to whoever wants go out.
Israel – its spokespersons recall – has been asking for weeks for the evacuation of hospitals to safer places to “be able to confront the terrorists” by denouncing that the armed wing of Hamas uses Shifa and the rest of Gaza's health centers to hide underground. and launch armed attacks. In this way, they warn of a future that may not be very distant, turning Shifa into a “legitimate military objective”. For the first time, Israeli sources do not rule out the possibility that some kidnapped people held by Hamas are in the basement of Gaza's main hospital.
The Army announced that they killed dozens of militiamen on the last day. Among them, Ahmed Siam, commander of the Naser Radwan company, whom he accused of “keeping approximately 1,000 Gaza residents hostage in the Rantisi Hospital, preventing them from evacuating to the south.”. According to the military organization, “he died at the Al Buraq school along with several other terrorists who were under his command and were hiding in the school.”. Hours earlier, the Ministry of Health had reported that the Israeli attack on that center had caused 50 deaths.
Four reservist soldiers died this Saturday due to the explosion of a tunnel located near a mosque in the northern Gaza Strip. In statements to foreign media, an officer from the Guivati Brigade in Gaza denounced the “presence of terrorists and Hamas tunnels in clinics, schools and mosques”. According to him, his forces surrounded the Rantisi Hospital after requesting its evacuation, pointing out that they saw militiamen camouflaged among the civilians who came out.. Hamas, for its part, denounced this Saturday “a ring of fire around the Indonesian Hospital.”
International NGOs and the UN warned of the effects of the siege and attacks in areas of the Shifa, Rantisi and Naser hospitals beyond the lack of fuel entry. World Health Organization (WHO) spokesperson Margaret Harris said the attack on Naser forced the closure of the children's hospital, the only specialized pediatric care hospital left in northern Gaza, while Doctors Without Borders added: ” We denounce the death sentence of civilians trapped in the Shifa hospital signed by the Israeli Army. An urgent and unconditional ceasefire is necessary for all warring parties. “Humanitarian aid must be provided to the entire Gaza Strip now.”
No supplies
“Overwhelmed, running on short supplies and increasingly insecure, Gaza's health system has reached a point of no return, endangering the lives of thousands of wounded, sick and displaced people,” said the International Committee of the Red Cross. (ICRC).
An Israeli government spokesman, Eylon Levy, said he regretted that WHO and UNWRA (the UN agency for Palestinian refugees) had not expressed “their indignation against the Hamas headquarters in the basement of Shifa Hospital or that they had committed to moving civilians to safety.
Meanwhile, thousands of Palestinians left through the two corridors (Salah A Din Highway and coastal road) of Israel, which this Saturday extended the humanitarian pause from four to seven hours.. In any case, it is an exodus of Palestinians in the Gaza Strip that will take a long time to rebuild their buildings destroyed by bombs.
Cameras captured an Israeli soldier shouting in Hebrew to the line of displaced people on the Salah A Din road: “If anyone speaks Hebrew, it's time, don't be afraid and come running here.”. Words born of fear or perhaps hope that Hamas troops have taken advantage of the mass departure to flee with some of the 239 kidnapped. In this sense, Israel launched leaflets in Arabic with a financial offer in exchange for information on the whereabouts of the hostages.. At the expense of a rescue mission that is very difficult in a strip full of tunnels, his release goes through negotiations led by Qatar, godfather of Hamas, Egypt, transcendental neighbor and gateway to Gaza, and the United States.
As Israeli ground incursion into northern Gaza progresses, Hamas has reduced its projectile launching capacity. Hamas and the rest of the armed groups have launched more than 9,500 projectiles against southern Israel (12% of those failed fell in Gaza, according to Israeli data). Among them, 3,000 in just a few hours on October 7. The armed wing of Hamas announced this Saturday that they have destroyed 160 armed military vehicles since the beginning of the ground operation. “Enemies carry out massacres (…) Israeli tanks face violent resistance and fierce clashes that force them to withdraw and change the course of the incursion,” he declared five weeks after their attack in southern Israel that sparked the war. .
Muslim countries unanimously condemn Israel in an unprecedented meeting in Riyadh
Leaders of the Arab League and the Organization of Islamic Cooperation unanimously condemned this Saturday in Riyadh the Israeli attacks in Gaza and the humanitarian crisis that has been unleashed in the Strip since last October 7. Saudi Arabia had planned two summits over the weekend, but joined the meetings to show a common position.
Both organizations seek to show a “unified collective stance that expresses the common Arab and Islamic will regarding the dangerous and unprecedented events witnessed in Gaza and the Palestinian territories,” they said in a statement.. Thus, representatives from 57 countries attended the summit, in which despite firmly condemning the Israeli attacks, the proposals of each country against Tel Aviv were very different.. From cutting relations with Israel to cutting off its gas and oil supplies or preventing the United States from using operational bases in the region to support Tel Aviv. The difference in proposals to resolve the conflict was also evident among the leaders: some advocated a two-state solution with the limits established in 1967 and others for a Palestinian State from the river to the sea, considering the entire territory of Palestine as Palestinian. Israel.
The summit was also unprecedented because it was the first time in many years that these countries met, in some cases faced by regional conflicts.. For example, it is the first time that Iranian President Ebrahim Raisi has visited Saudi Arabia since both countries normalized relations in March with the mediation of China.. It had been 11 years since an Iranian president had set foot in Riyadh. It is also the first face-to-face meeting between Turkish President Recep Tayyip Erdogan and his Syrian counterpart Bashar Assad.. For the latter, it is also the first summit he has attended since he was readmitted to the Arab League in May, after 12 years of absence during the Syrian war.
During the round of interventions, the most forceful leader was Raisi – whose country supports Hamas – who asked Islamic governments to designate Israel as a “terrorist organization” and urged them to impose economic sanctions.. He proposed banning the sale of weapons to Israel and establishing a no-fly zone for Israeli flights until the conflict is resolved.. “The United States supports Israel at the UN and vetoes resolutions that prevent the slaughter of Palestinians. “It has paved the way for Israel to kill more and bomb more,” he said during his speech.. “Blind bombing of Gaza must stop. The entire Islamic world must be united. With this unit we can solve the problem,” he added.
Tomorrow
On the other hand, Raisi celebrated Hamas' performance in the conflict and asked to “support the resistance and kiss the hands and forehead of each member of the Palestinian resistance.”. For his part, Saudi Crown Prince Mohammed bin Salman noted that the current situation is a “failure of the international community and the UN Security Council.”. He called for an end to the “Israeli occupation and illegal settlements” and supported establishing the boundaries of a Palestinian state on the 1967 borders, with East Jerusalem as its capital.. Turkish President Recep Tayyip Erdogan went one step further and tried to deal with a scenario after the cessation of the conflict.. “An international peace conference should be called to find a permanent solution to the conflict between Israelis and Palestinians,” he said.. “What is needed in Gaza is not pauses of a couple of hours, but a permanent ceasefire,” he added.
The Emir of Qatar, Tamim bin Hamad Al Thani, reiterated his country's mediation efforts to secure the release of Israeli and foreign hostages in Gaza and noted that they hope for a humanitarian truce in the Strip.. “The international community has not fulfilled its legal and ethical responsibilities,” he said during the meeting.. “How long will the international community treat Israel as if it were above international law?” he asked.
During the summit, UN refugee chief Philippe Lazzarini sent a video message to Islamic leaders, asking them to continue pushing to increase the flow of humanitarian aid into the Gaza Strip.. “The people of Gaza have always counted on Arab support and solidarity. “Now they need it more than ever,” he said, while calling for financial support for the organization, the largest humanitarian entity on the ground.
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France toughens its immigration law
The new immigration law of the French Government, which was presented as “balanced” and which has begun its parliamentary journey these days, has toughened its content. In the first week of debate in the Senate, which concluded this Friday, measures have been approved to facilitate the expulsion of foreigners who have committed crimes, do not respect the values of the Republic or pose a serious threat to the country.. Furthermore, the only article that could satisfy the left and the immigrant associations has been decaffeinated: that of the regularization of undocumented people who work in jobs where there is hardly any labor.
The debate started on Monday. The Minister of the Interior, Gérald Darmanin, had said that the project sought to “be good with the good and bad with the bad.”. The original text contained measures to please the left and the right. However, day by day the content has been tweaked, making more concessions to the latter, who considered the text to be too lax.. On Monday, for example, they voted in favor of withdrawing the State medical assistance device that the undocumented benefited from.. Instead, there will be emergency medical help.
Expulsions are made easier, the asylum application is complicated and the conditions for family reunification are also toughened.. The article that provided for the regularization of people in an illegal situation who work in sectors without labor such as hospitality or construction, has remained minimal.
Now, what has been voted is that the prefects of each region be the ones to assess each case individually, evaluating not only the work that the immigrant performs, but also their integration and whether they respect the values of the Republic.. The Republican party, key to the Government to move the text forward in the Assembly, asked that it be eliminated. Also the extreme right. It was one of the few concessions to the left, which from the beginning has described the text as excessively restrictive.
One of the priority objectives is to facilitate the expulsions of foreigners who have committed crimes.. To do this, the protections that some benefit from and that prevented them from being kicked out will be eliminated.. This is the case of those who are under 13 years old when they arrive in French territory, for example.
For this reason, the jihadist of Chechen origin who stabbed a teacher a little over a month ago in a high school in the north of the country could not be expelled from France.. Despite being booked for radicalization, he had arrived in France when he was less than 13 years old.
Those who have a final sentence of more than five years in prison will no longer benefit from that protection. Darmanin, who has been posting on Twitter (now. “The French do not understand that someone who has committed a crime cannot be expelled,” the minister had denounced.
The residence permit will also be withdrawn from those who do not respect the values of the Republic.. These, according to the text, are personal freedom, freedom of expression and conscience, equality between men and women, human dignity and respect for the symbols of the Republic.
Wearing “ostentatious religious clothing” or “spitting on the French flag in a patriotic ceremony” are some examples of non-respect for the aforementioned values, as Darmanin illustrated in the Senate.
Another controversial measure: until now, children born in France to foreign parents automatically obtain nationality upon reaching the age of majority.. This right is eliminated and they will have to expressly request it from the age of 16 to 18.. And those who have been sentenced to a sentence of more than six months in prison will not be able to do so.
Immigrant and anti-racism associations have written a letter to the Prime Minister, Elisabeth Borne, to criticize this “unknown restriction of rights” until now.. “Access to French nationality favors immigration,” had defended Republican senator Valérie Boyer. The text ended the debate today in the Senate, where it will be voted next Tuesday. It will then go to the Assembly, which will begin processing it from December 11. The idea is that it will come into force at the beginning of next year.
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INVESTMENT
It's official: foreign companies are leaving China
In the third quarter, foreign companies have taken more money out of China than they have put into that economy. It is the first time since that country began publishing statistics
UK begins using drug to prevent breast cancer in postmenopausal women
The hormonal drug anastrozole is one of the therapeutic options commonly used for breast cancer in postmenopausal women.. Now, the Medicines and Healthcare products Regulatory Agency (MHRA) in the United Kingdom also allows its use to prevent this tumor in women at risk.
The indication is extended to postmenopausal women with moderate or high risk of developing the disease, who could number around 289,000 in the United Kingdom, according to estimates from the British National Health Service (NHS).
“This is the first medicine to be repurposed through a new world-leading program to help us harness the full potential of existing medicines into new uses to save and improve more lives in the NHS.. Through this initiative, we hope that greater access to anastrozole will allow more women to take steps to reduce their risk if they wish, helping them live without fear of breast cancer,” said Amanda Pritchard, chief executive of the NHS, in a statement.. “It's fantastic that this vital risk-reducing option can now help thousands of women and their families avoid the heartbreak of a breast cancer diagnosis.”
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Prophylactic treatment consists of one 1 mg tablet, once a day for 5 years.. Anastrozole is an aromatase inhibitor, which, by blocking that enzyme, reduces the amount of estrogen produced by the body.
Are there side effects after taking the drug?
The most common side effects of the medication are hot flashes, feeling weak, joint pain or stiffness, arthritis, rash, nausea, headache, osteoporosis, and depression.
The decision to use the drug as a preventive treatment, according to the MHRA, is based on the evidence provided by the IBIS-II study, an international, randomized, double-blind, placebo-controlled trial, which showed that women receiving anastrazole developed fewer breast tumors than those in the placebo group.
Judith Balmaña, medical oncologist from Vall d'Hebron, head of the VHIO Hereditary Cancer Genetics Group and member of the SOLTI cancer research group, values the measure adopted in this medium because “it involves caring for people from a health perspective, in health, to reduce your risk of developing a disease.
The specialist points out that this is progressing along a path in which little by little “we make increasingly personalized risk estimates, for which risk-reducing measures can then be provided, whether pharmacological or not.”. Although the oncologist is in favor of starting with non-pharmacological ones, since you always have to weigh the side effects of the medications.
What is the impact of this drug?
However, it stands out that anastrozole – which, together with tamoxifen, has this indication in the United Kingdom to prevent breast cancer – showed in a clinical study its effectiveness in reducing the probability of developing the tumor by half, a not trivial figure.. “From there it is interesting to start this conversation about the measures that allow health care to be carried out from health,” he reflects..
The IBIS-II study was published in 2019 in The Lancet, with Jack Cuzick of Queen Mary University of London as lead author.. The results then published were based on data from 3,864 study participants (1,920 received anastrazole for five years, and 1,944 received placebo).
The model to assign the level of risk of hormonal cancer in women took into account factors such as family history, breast density, obesity, alcohol consumption and a premalignant lesion, among others.
Follow-up extended over a period of 12 years, with a median of 10.9 years. At 12 years (seven after stopping treatment), the incidence of breast cancer was found to be 49% lower in those taking the drug than in women receiving a placebo.
What is drug adherence like?
Additionally, the researchers also reported that there were no significant long-term side effects in the years after stopping anastrozole treatment, particularly an increase in bone fractures or disease.
Adherence during the five years of taking the tablets was 77% in the placebo group and 74.6% in the anastrozole group. Suggesting that the side effects were not severe enough to deter taking the drug.
Great advance towards artificial life: they 'manufacture' a cell with more than half of its synthetic DNA
A team of scientists based in the United Kingdom has just achieved one of the greatest achievements in the history of artificial biology, after managing to develop for the first time a yeast cell, which is capable of surviving and multiplying like natural ones, but with more than half of its genome created in a laboratory.
The researchers, who have just published their results in the journal Cell Genomics, have managed to construct one of the 16 chromosomes of the yeast genome and insert it into a natural cell. Dr. Ben Blount, professor at the School of Life Sciences at the University of Nottingham, and one of the main signatories of the project, said that this discovery “will open up an enormous range of possibilities, from the creation of new microbial strains for a more ecological bioproduction, to helping us understand and combat diseases.
Yeast was the organism chosen for the project because it has a relatively compact genome, and the innate ability to join DNA, allowing researchers to build synthetic chromosomes within yeast cells.
The chromosome, known as 'Sc2.0', has seen the light after 15 years of work and the participation of teams from all over the world (United Kingdom, USA. USA, China, Singapore, UK, France and Australia), who have worked together to create synthetic versions of all yeast chromosomes.
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Humans have a long history with yeast, researchers explain, having domesticated it for baking and brewing for thousands of years and, more recently, for chemical production or as a model organism for how our own cells work.. This means we know more about the genetics of yeast than any other organism, which made it the obvious candidate.
“A cell has not been created, what has been done is to synthesize an important part of the genome, which is already a merit in itself, and insert it into already existing cells,” explains Jordi García Ojalvo, professor of Systems Biology at Pompeu Fabra University of Barcelona. “It is important to note that, so far, we have not been able to generate cells from scratch. All the cells that exist on Earth come from a first primordial cell that appeared almost four billion years ago, which has divided an enormous number of times to give rise to each and every one of the cells of all the organisms that exist. in the planet. “We can create artificial genomes, but we cannot yet create artificial life, because the unit of life, the cell, is still out of our reach.”
The artificially constructed DNA sequence consists of around 660,000 pairs, which are the “letters” that make up the DNA code.. The synthetic chromosome replaced one of the natural chromosomes of a yeast cell and, after a thorough purification process, it was able to develop like a natural cell.
The synthetic genome will not only help scientists understand how genomes work. Instead of being a direct copy of the natural genome, the Sc2.0 synthetic genome has been designed with special characteristics, which give cells capabilities not found in nature. One of them forces cells to mix their genetic content, creating millions of different versions of cells with new characteristics.. From there, those with improved properties can be selected for a wide range of applications in medicine, bioenergy and biotechnology.. The process, the researchers explain, “is a supercharged form of evolution.”
The team has also shown that their chromosome can be reused to study extrachromosomal circular DNA (eccDNA).. These are free-floating circles of DNA that have fallen out of the genome and are believed to be responsible for aging, or the malignant growth and resistance to chemotherapy drugs of many cancers, including glioblastoma brain tumors.